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Contrary to popular belief, there is NOT a Federal law that prohibits truckers from carrying on the truck for self defense. If there was, it would create serious Constitutional case law issues.
Carrying a firearm in your vehicle legally is dependent on what state you are in, and what the laws are in that state, so it would be very advisable for a driver to check the state's regulations concerning the carrying of firearms in their vehicle, but there is no one "law" that says that a trucker can't have a firearm in their truck.
The Supreme Court in District of Columbia v. Heller held that The Second Amendment protects an individual right to possess a firearm unconnected with service in a militia, and to use that arm for traditionally lawful purposes, such as self-defense within the home. The Supreme Court in McDonald v. Chicago extended that right to be made applicable against the states via the due process clause of the Fourteenth Amendment.
Trucking Industry Carriers across this nation need to recognize this issue, and reverse their policies to allow their employee drivers to protect themselves while on the job when sending them into dangerous places. Let this be a gathering point for Commercial Drivers with CDLs to discuss ways to make this happen.